This gene encodes the peroxisomal enzyme D-amino acid
oxidase. The enzyme is a flavoprotein which uses flavin adenine
dinucleotide (FAD) as its prosthetic group. Its substrates include
a wide variety of D-amino acids, but it is inactive on the
naturally occurring L-amino acids. Its biological function is not
known; it may act as a detoxifying agent which removes D-amino
acids that accumulate during aging. In mice, it degrades D-serine,
a co-agonist of the NMDA receptor. This gene may play a role in the
pathophysiology of schizophrenia.1) Kim, B., et al. Psychiatry Res 179(2):121-125(2010)
Immunogen
This DAO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 amino acids from the Central region of human DAO.
Western blot analysis in Jurkat cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.