Application
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with DCX Antibody (S128) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.Application
Western blot analysis of lysate from human brain tissue lysate, using Phospho-DCX-S128. ctrl at 1:1000 at each lane.| Product Name | DCX Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX |
| Product description | In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.1) Leger,P.L., Neurogenetics (2008) |
| Immunogen | This DCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from human DCX. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DCX |
|---|---|
| Alternative Names | Neuronal migration protein doublecortin Doublin Lissencephalin-X Lis-X DCX DBCN LISX |
| Molecular Weight(MW) | 49 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse |
Application
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with DCX Antibody (S128) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Application
Western blot analysis of lysate from human brain tissue lysate, using Phospho-DCX-S128. ctrl at 1:1000 at each lane.| Application Notes | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
