Application
Immunohistochemistry staining of DDB1 in brain cortex tissue using DDB1 Antibody.| Product Name | DDB1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DDB1, DDB p127 subunit, DDBA, HBV X-associated protein 1, UV-DDB1, XAP-1, XPE, XPE-binding factor, UV-damaged DNA-binding factor, XPCE, DNA damage-binding protein 1, DNA damage-binding protein a, UV-DDB 1, XAP1, XPE-BF |
| Product description | DDB1 is also known as damage-specific DNA binding protein 1, DDB p127 subunit, DDBa, UV-damaged DNA-binding protein 1, UV-DDB 1, Xeroderma pigmentosum group E complementing protein, XPCe, X-associated protein 1 and XAP-1. The DDB1 gene encodes the large subunit (p127) of DNA damage-binding protein, which is a heterodimer, composed of a large and a small subunit (p48 DDB2). This nuclear protein functions in nucleotide-excision repair resulting from UV-damaged DNA by binding to pyrimidine dimers. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). XP-E is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. |
| Immunogen | DDB1 antibody was raised against amino acids 198-213 internal region of DDB1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| DDB1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | DDB1 |
|---|---|
| Alternative Names | DDB1 DDB p127 subunit DDBA HBV X-associated protein 1 UV-DDB1 XAP-1 XPE XPE-binding factor UV-damaged DNA-binding factor XPCE DNA damage-binding protein 1 DNA damage-binding protein a UV-DDB 1 XAP1 XPE-BF |
Application
Immunohistochemistry staining of DDB1 in brain cortex tissue using DDB1 Antibody.| Application Notes | DDB1 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store DDB1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.01% sodium azide. |
