ATP-dependent RNA helicase DDX3Y, DEAD box protein 3, Y-chromosomal, DDX3Y, DBY
Product description
DEAD box proteins, characterized by the conserved motif
Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration
of RNA secondary structure such as translation initiation, nuclear
and mitochondrial splicing, and ribosome and spliceosome assembly.
Based on their distribution patterns, some members of this family
are believed to be involved in embryogenesis, spermatogenesis, and
cellular growth and division. This gene encodes a DEAD box protein,
and it has a homolog on the X chromosome. The gene mutation causes
male infertility, Sertoli cell-only syndrome or severe
hypospermatogenesis, suggesting that this gene plays a key role in
the spermatogenic process. Alternatively spliced variants, encoding
the same protein, have been identified.1) Rosinski, K.V., et al. Blood 111(9):4817-4826(2008)
Immunogen
This DDX3Y antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the N-terminal region of human DDX3Y.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.