Application
Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.| Product Name | DR6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6 |
| Product description | DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.1) Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998;431:351-6 |
| Immunogen | DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6. The immunogen is located within amino acids 30 - 80 of DR6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TNFRSF21 |
|---|---|
| Alternative Names | DR6 Antibody: DR6 CD358 BM-018 DR6 UNQ437/PRO868 Tumor necrosis factor receptor superfamily member 21 Death receptor 6 |
| Molecular Weight(MW) | 68 kDa |
| Sequence Similarities | 2) Cat. No. 1204 - K562 Cell Lysate |
Application
Western blot analysis of DR6 in K562 (1,3) and Raji (2,4) whole cell lysate in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.| Positive Control | 1) Cat. No. 1201 - HeLa Cell Lysate |
|---|---|
| Application Notes | DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected.: |
| Form | Liquid |
|---|---|
| Storage Instructions | DR6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | DR6 Antibody is supplied in PBS containing 0.02% sodium azide. |
