Dual specificity protein phosphatase 13 isoform A, DUSP13A, Branching-enzyme interacting DSP, Muscle-restricted DSP, MDSP, DUSP13, BEDP, DUSP13A, MDSP
Product description
Members of the protein-tyrosine phosphatase superfamily
cooperate with protein kinases to regulate cell proliferation and
differentiation. This superfamily is separated into two families
based on the substrate that is dephosphorylated. One family, the
dual specificity phosphatases (DSPs) acts on both phosphotyrosine
and phosphoserine/threonine residues. This gene encodes different
but related DSP proteins through the use of non-overlapping open
reading frames, alternate splicing, and presumed different
transcription promoters. Expression of the distinct proteins from
this gene has been found to be tissue specific and the proteins may
be involved in postnatal development of specific tissues. A protein
encoded by the upstream ORF was found in skeletal muscle, whereas
the encoded protein from the downstream ORF was found only in
testis. In mouse, a similar pattern of expression was found.
Multiple alternatively spliced transcript variants were described,
but the full-length sequence of only some were determined.1) Kim, S.J., et al. Proteins 66(1):239-245(2007)
Immunogen
This DUSP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-173 amino acids from the C-terminal region of human DUSP13.
Western blot analysis in A2058 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.