Application
Antibody used in WB on Human K562 at 2.5 ug/ml.| Product Name | DVL1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DVL1, DVL, MGC54245, DVL1L1, DVL1P1 |
| Product description | DVL1 is a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 gene is a candidate for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1 gene. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.1) Mizutani, K., (2005) Am. J. Clin. Oncol. 91 (6), 546-551. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DVL1. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| DVL1 antibody can be used for detection of DVL1 by ELISA at 1:62500. DVL1 antibody can be used for detection of DVL1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | DVL1 |
|---|---|
| Alternative Names | DVL1 DVL MGC54245 DVL1L1 DVL1P1 |
| Molecular Weight(MW) | 73 kDa |
Application
Antibody used in WB on Human K562 at 2.5 ug/ml.| Positive Control | 1) Cat. No. 1204 - K562 Cell Lysate |
|---|---|
| Application Notes | DVL1 antibody can be used for detection of DVL1 by ELISA at 1:62500. DVL1 antibody can be used for detection of DVL1 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store DVL1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt |
