Application
Immunohistochemistry staining of Endoglin in liver tissue using Endoglin Antibody.| Product Name | Endoglin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ENG, CD105, CD105 antigen, END, HHT1, ORW, ORW1, Osler-Rendu-Weber syndrome 1, Endoglin |
| Product description | CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an Oand N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-β1 and Beta3 with high affinity but not TGF-β2. Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Endoglin has been shown to be a useful marker to identify tumor angiogenesis. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia. |
| Immunogen | Endoglin antibody was raised against amino acids 26 - 176 of Endoglin (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| Endoglin antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ENG |
|---|---|
| Alternative Names | ENG CD105 CD105 antigen END HHT1 ORW ORW1 Osler-Rendu-Weber syndrome 1 Endoglin |
| Tissue Specificity | Recognizes human CD105. |
Application
Immunohistochemistry staining of Endoglin in liver tissue using Endoglin Antibody.| Application Notes | Endoglin antibody can be used in ELISA, and immunohistochemistry starting at 5 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Endoglin antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, before the addition of glycerol to 40% |
