Application
Western blot analysis of SW480 in SW480 cell lysate with EPM2A antibody at (A) 1 and (B) 2 μg/mL.Application
Immunofluorescence of EPM2A in SW480 cells with EPM2A antibody at 5 μg/ml.Application
Immunocytochemistry of EPM2A in SW480 cells with EPM2A antibody at 2.5 μg/ml.| Product Name | EPM2A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EPM2A Antibody: EPM2, MELF, Laforin, Lafora PTPase, LAFPTPase |
| Product description | EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.1) Minassian BA, Lee JR, Herbrick JA, et al. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat. Genet. 1998; 20:171-4. |
| Immunogen | EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A. The immunogen is located within amino acids 190 - 240 of EPM2A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICCIFWB |
| EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | EPM2A |
|---|---|
| Alternative Names | EPM2A Antibody: EPM2 MELF Laforin Lafora PTPase LAFPTPase |
| Molecular Weight(MW) | 36 kDa |
| Tissue Specificity | At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform. |
Application
Western blot analysis of SW480 in SW480 cell lysate with EPM2A antibody at (A) 1 and (B) 2 μg/mL.
Application
Immunofluorescence of EPM2A in SW480 cells with EPM2A antibody at 5 μg/ml.
Application
Immunocytochemistry of EPM2A in SW480 cells with EPM2A antibody at 2.5 μg/ml.| Positive Control | 1) Cat. No. 1221 - SW480 Cell Lysate |
|---|---|
| Application Notes | EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | EPM2A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | EPM2A Antibody is supplied in PBS containing 0.02% sodium azide. |
