Application
Western blot analysis of extracts from K562 tissue using Epo-R (Phospho-Tyr368) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | Epo-R (phospho Tyr368) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EPO R, EPO-R, epor |
| Product description | Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.1) Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 |
| Immunogen | Epo-R (phospho Tyr368) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y (p)-L-V) derived from Human Epo-R. |
| Modification | p-Tyr368 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | EPOR |
|---|---|
| Alternative Names | EPO R EPO-R epor |
| Molecular Weight(MW) | 55 kDa |
| Tissue Specificity | The antibody detects endogenous level of Epo-R only when phosphorylated at tyrosine 368. |
| Entrez Gene | 2057 |
|---|---|
| Protein Accession | NP_000112.1 |
Application
Western blot analysis of extracts from K562 tissue using Epo-R (Phospho-Tyr368) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
