Application
Western blot analysis of ERAP2 in human ovary tissue lysate with ERAP2 antibody at 1 μg/ml.| Product Name | ERAP2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERAP2 Antibody : LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase |
| Product description | The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1). Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3).1) Saveanu L, Carroll O, Lindo V, et al. Concerted peptide trimming by EARP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 2005; 6:689-97. |
| Immunogen | ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2. The immunogen is located within amino acids 110 - 160 of ERAP2 . |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μg/ml.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ERAP2 |
|---|---|
| Alternative Names | ERAP2 Antibody : LRAP L-RAP LRAP Endoplasmic reticulum aminopeptidase 2 Leukocyte-derived arginine aminopeptidase |
| Molecular Weight(MW) | Predicted: 106 kDa Observed: 120kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (75%) |
| Tissue Specificity | ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1. |
Application
Western blot analysis of ERAP2 in human ovary tissue lysate with ERAP2 antibody at 1 μg/ml.| Positive Control | 1) Cat. No. 1316 - Human Ovary Tissue Lysate |
|---|---|
| Application Notes | ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μg/ml.: |
| Form | Liquid |
|---|---|
| Storage Instructions | ERAP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide. |
