Application
Western blot analysis in HL-60 cell line lysates (35ug/lane).| Product Name | ERI2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERI1 exoribonuclease 2, 31--, Exonuclease domain-containing protein 1, ERI2, EXOD1, KIAA1504 |
| Product description | EXOD1 (Exonuclease domain-containing protein 1), also known as ERI2 (ERI1 exoribonuclease 2), is a 691 amino acid protein that contains one exonuclease domain, which catalyzes the hydrolysis of unpaired or mismatched nucleotides. EXOD1 acitivity is dependent on the binding of two magnesium ions per subunit. There are four isoforms of EXOD1 that are produced as a result of alternative splicing events. The gene encoding EXOD1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) |
| Immunogen | This ERI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-472 amino acids from the Central region of human ERI2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ERI2 |
|---|---|
| Alternative Names | ERI1 exoribonuclease 2 31-- Exonuclease domain-containing protein 1 ERI2 EXOD1 KIAA1504 |
| Molecular Weight(MW) | 77 kDa |
Application
Western blot analysis in HL-60 cell line lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
