Application
Antibody is used in Western blot to detect ERN2 in mouse liver tissue lysate| Product Name | ERN2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN2 ( HGNC:16942 ) |
| Product description | ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.1) Iwawaki, T., et al., Nat. Cell Biol. 3(2):158-164 (2001). |
| Immunogen | This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-810 amino acids from the C-terminal region of human ERN2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | ERN2 |
|---|---|
| Alternative Names | Serine/threonine-protein kinase/endoribonuclease IRE2 Endoplasmic reticulum-to-nucleus signaling 2 Inositol-requiring protein 2 hIRE2p Ire1-beta IRE1b Serine/threonine-protein kinase Endoribonuclease 3126- ERN2 ( HGNC:16942 ) |
| Molecular Weight(MW) | 102 kDa |
Application
Antibody is used in Western blot to detect ERN2 in mouse liver tissue lysate| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
