Application
Western blot analysis in MCF-7 cell line and human placenta tissue lysates (35ug/lane).| Product Name | ESR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2 |
| Product description | This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.1) Fang, Y.J., et al. Tumour Biol. 31(6):651-658(2010) Hayes, D.F., et al. Clin. Pharmacol. Ther. 88(5):626-629(2010) Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010)Wurster, M., et al. Oncol. Rep. 24(3):653-659(2010) Paulus, J.K., et al. Lung Cancer (2010) In press : |
| Immunogen | This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 451-480 amino acids from the C-terminal region of human ESR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ESR2 |
|---|---|
| Alternative Names | Estrogen receptor beta ER-beta Nuclear receptor subfamily 3 group A member 2 ESR2 ESTRB NR3A2 |
| Molecular Weight(MW) | 59 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine |
Application
Western blot analysis in MCF-7 cell line and human placenta tissue lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
