Application
Immunofluorescence of EVER1 in Human Spleen cells with EVER1 antibody at 20 μg/mL.| Product Name | EVER1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EVER1 Antibody: EV1, EVER1, EVIN1, LAK-4P, Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1 |
| Product description | EVER1 Antibody: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes, EVER1 and EVER2, located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. Both EVER1 and EVER2 are members of the transmembrane channel-like (TMC) protein family. EVER1 possesses eight trans-membrane domains and two leucine zipper motifs. EVER1 and EVER2 form a complex and interact with the zinc transporter 1 (ZnT-1), suggesting that EVER1 and EVER2 act to regulate cellular zinc balance.1) Majewski S, Jablonska J and Orth G. Epidermodysplasia verruciformis. Immunological and nonimmunological surveillance mechanisms: role in tumor progression. Clin. Dermatol.1997; 15:321-34. |
| Immunogen | EVER1 antibody was raised against a 15 amino acid synthetic peptide from near the center of human EVER1. The immunogen is located within amino acids 560 - 610 of EVER1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TMC6 |
|---|---|
| Alternative Names | EVER1 Antibody: EV1 EVER1 EVIN1 LAK-4P Transmembrane channel-like protein 6 Epidermodysplasia verruciformis protein 1 |
| Sequence Similarities | 2) Cat. No. 10-901 - Human Spleen Tissue Slide |
| Tissue Specificity | At least four isoforms of EVER1 are known to exist. This EVER1 antibody does not cross-react with EVER2. |
Application
Immunofluorescence of EVER1 in Human Spleen cells with EVER1 antibody at 20 μg/mL.| Positive Control | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
|---|---|
| Application Notes | EVER1 antibody can be used for the detection of EVER1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | EVER1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | EVER1 Antibody is supplied in PBS containing 0.02% sodium azide. |
