This gene encodes a core component of the exosome. The
mammalian exosome is required for rapid degradation of AU rich
element-containing RNAs but not for poly(A) shortening. The
association of this protein with the exosome is mediated by
protein-protein interactions with ribosomal RNA-processing protein
42 and ribosomal RNA-processing protein 46.1) Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Immunogen
This EXOSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-191 amino acids from the C-terminal region of human EXOSC1.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.