Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.1) Zhou R, et al. (2005) J Cell Sci: 118 (Pt 19): 4381-91Shiue H, et al. (2005) J Biol Chem: 280 (2): 1688-95Zhao H, et al. (2004) Proc Natl Acad Sci U S A: 101 (25): 9485-90Fievet BT, et al. (2004) J Cell Biol: 164 (5): 653-9
Immunogen
Ezrin (Phospho-Thr567) antibody was raised against a peptide sequence around phosphorylation site of threonine 567 (Y-K-T (p) -L-R) derived from Human Ezrin.