Application
Immunohistochemistry of FAIM2 in mouse brain tissue with FAIM2 antibody at 5 μg/mL.Application
Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 μg/mL.| Product Name | FAIM2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FAIM2 Antibody: LFG, LFG2, NGP35, NMP35, TMBIM2, KIAA0950, LFG, Protein lifeguard 2, Fas apoptotic inhibitory molecule 2 |
| Product description | FAIM2 Antibody: Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.1) Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7. |
| Immunogen | FAIM2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2. The immunogen is located within the first 50 amino acids of FAIM2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| FAIM2 antibody can be used for detection of FAIM2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FAIM2 |
|---|---|
| Alternative Names | FAIM2 Antibody: LFG LFG2 NGP35 NMP35 TMBIM2 KIAA0950 LFG Protein lifeguard 2 Fas apoptotic inhibitory molecule 2 |
| Sequence Similarities | 2) Cat. No. 1402 - Mouse Lung Tissue Lysate |
Application
Immunohistochemistry of FAIM2 in mouse brain tissue with FAIM2 antibody at 5 μg/mL.
Application
Western blot analysis of FAIM2 in EL4 cell lysate with FAIM2 antibody at (A) 0.5 and (B) 1 μg/mL.| Positive Control | 1) Cat. No. 1287 - EL4 Cell Lysate |
|---|---|
| Application Notes | FAIM2 antibody can be used for detection of FAIM2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | FAIM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | FAIM2 Antibody is supplied in PBS containing 0.02% sodium azide. |
