FAM212A, initially identified as INCA (induced in neural crest by AP-2alpha) in xenopus, is expressed primarily in neural crest cells and their derivatives (1). FAM212A can associate with the P21-kinase protein PAK4 and this association modulates cytoskeletal dynamics (1). In mammals, FAM212A is thought to play a role in neural tube closure; a significant fraction of FAM212A-null mice exhibited exencephaly (2).1) Luo T, Xu Y, Hoffman TL, et al. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Dev. 2007; 134:1279-89.
Immunogen
FAM212A antibody was raised against a 15 amino acid peptide near the carboxy terminus of human FAM212A. The immunogen is located within the last 50 amino acids of FAM212A.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
ELISAWB
FAM212A antibody can be used for detection of FAM212A by Western blot at 1 - 2 μg/ml.