This gene was originally isolated through subtractive
hybridization due to its increased expression in differentiated
chondrocytes versus dedifferentiated chondrocytes. The resulting
protein contains a predicted ezrin-like domain, a Dbl homology
domain, and a pleckstrin homology domain. It is believed to be a
member of the band 4.1 superfamily whose members link the
cytoskeleton to the cell membrane. Two alternatively spliced
transcript variants encoding distinct isoforms have been found for
this gene.1) Stein, J.L., et al. Neuroimage 53(3):1160-1174(2010)
Immunogen
This FARP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the N-terminal region of human FARP1.
FERM RhoGEF and pleckstrin domain-containing protein 1 Chondrocyte-derived ezrin-like protein Pleckstrin homology domain-containing family C member 2 PH domain-containing family C member 2 FARP1 CDEP PLEKHC2
Molecular Weight(MW)
119 kDa
Sequence Similarities
Predicted species reactivity based on immunogen sequence: Chicken
Western blot analysis in A375 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.