This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.1) "Winston J. T., et al. (1999) Curr. Biol. 9:1180-1182. Carninci P. et al. (2005) Science 309:1559-1563. The MGC Project Team, (2004) Genome Res. 14:2121-2127.
Immunogen
FBXL3 antibody was raised against a peptide sequence around aa.1~5 (M-K-R-G-G) derived from mouse FBXL3 .