This gene encodes a member of the F-box protein family
which is characterized by an approximately 40 amino acid motif, the
F-box. The F-box proteins constitute one of the four subunits of
the ubiquitin protein ligase complex called SCFs
(SKP1-cullin-F-box), which function in phosphorylation-dependent
ubiquitination. The F-box proteins are divided into 3 classes: Fbws
containing WD-40 domains, Fbls containing leucine-rich repeats, and
Fbxs containing either different protein-protein interaction
modules or no recognizable motifs. The protein encoded by this gene
belongs to the Fbxs class. It is also a member of the NFB42 (neural
F Box 42 kDa) family, similar to F-box only protein 2 and F-box
only protein 6. Four alternatively spliced transcript variants
encoding two distinct isoforms have been found for this gene.1) Kumanomidou, T., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 1), 95-98 (2010) :
Immunogen
This FBXO44 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-50 amino acids from the N-terminal region of human FBXO44.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.