Application
Antibody is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. Data is kindly provided by Dr. Masaru Harada from Stanford University (Palo Alto, CA).Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.| Product Name | FDPS Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Farnesyl pyrophosphate synthase, FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293 |
| Product description | The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.1) Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002). |
| Immunogen | This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For IHC-P starting dilution is: 1:10~50 For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | FDPS |
|---|---|
| Alternative Names | Farnesyl pyrophosphate synthase FPP synthase FPS (2E 6E)-farnesyl diphosphate synthase Dimethylallyltranstransferase Farnesyl diphosphate synthase Geranyltranstransferase FDPS FPS KIAA1293 |
| Molecular Weight(MW) | 48 kDa |
Application
Antibody is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. Data is kindly provided by Dr. Masaru Harada from Stanford University (Palo Alto, CA).
Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center ), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.| Application Notes | For IHC-P starting dilution is: 1:10~50 For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
