FERMT2 participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.1) An, Z., et al. Int. J. Cancer 127(9):1999-2008(2010) Bledzka, K., et al. J. Biol. Chem. 285(40):30370-30374(2010) Lai-Cheong, J.E., et al. Int. J. Biochem. Cell Biol. 42(5):595-603(2010) Lai-Cheong, J.E., et al. J. Invest. Dermatol. 128(9):2156-2165(2008) Ma, Y.Q., et al. J. Cell Biol. 181(3):439-446(2008)
Immunogen
This FERMT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-669 amino acids from the C-terminal region of human FERMT2.
Fermitin family homolog 2 Kindlin-2 Mitogen-inducible gene 2 protein MIG-2 Pleckstrin homology domain-containing family C member 1 PH domain-containing family C member 1 FERMT2 KIND2 MIG2 PLEKHC1
Molecular Weight(MW)
78 kDa
Sequence Similarities
Predicted species reactivity based on immunogen sequence: Zebrafish
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.