| Product Name | FGF-19 Antibody [FG369-1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | FGF-19 is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB. |
| Immunogen | Recombinant human FGF-19. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1, k |
| Host Species | Mouse |
| Tested Applications | ELISAIHCWB |
| ELISA: (direct or indirect: 1:2,000-1:5,000), Immunohistochemistry: (paraffin sections, 15ug/ml). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | FGF19 |
|---|---|
| Alternative Names | Fibroblast Growth Factor 19 |
| Tissue Specificity | Recognizes human FGF-19. Detects a band of ~25kDa by Western blot. |
| Application Notes | ELISA: (direct or indirect: 1:2,000-1:5,000), Immunohistochemistry: (paraffin sections, 15ug/ml). Western blot: (1:2,000-1:5,000 using ECL. Suggested blocking and dilution buffer is PBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives. |
Data sheet for OM278771