Application
Western blot analysis of extracts from HepG2 cells using FGFR1/2 (Phospho-Tyr463/466) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | FGFR1/2 (phospho Tyr463/466) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.1) Itoh N., Biochem. Biophys. Res. Commun. 169:680-685(1990). |
| Immunogen | FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p)-E-L) derived from Human FGFR1/2. |
| Modification | p-Tyr463/466 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FGFR1, FGFR2 |
|---|---|
| Alternative Names | BFGFR CEK FLG CD331 FLT2 |
| Molecular Weight(MW) | 91 kDa |
| Tissue Specificity | The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466. |
| Entrez Gene | 2260/2263 |
|---|---|
| Protein Accession | NP_075598.2 |
Application
Western blot analysis of extracts from HepG2 cells using FGFR1/2 (Phospho-Tyr463/466) Antibody. The lane on the right is treated with the antigen-specific peptide.| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
