Application
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 μg/mL.Application
Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | FNIP2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FNIP2 Antibody: FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein |
| Product description | FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.1) Hasumi H, Baba M, Hong S-B, et al. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene2008; 415:60-7. |
| Immunogen | FNIP2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human FNIP2. The immunogen is located within amino acids 860 - 910 of FNIP2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| FNIP2 antibody can be used for detection of FNIP2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | FNIP2 |
|---|---|
| Alternative Names | FNIP2 Antibody: FNIPL MAPO1 FNIPL KIAA1450 Folliculin-interacting protein 2 FNIP1-like protein |
| Tissue Specificity | Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1. |
Application
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 μg/mL.
Application
Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate |
|---|---|
| Application Notes | FNIP2 antibody can be used for detection of FNIP2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | FNIP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | FNIP2 Antibody is supplied in PBS containing 0.02% sodium azide. |
