This gene encodes a member of the folate receptor (FOLR)
family, members of which have a high affinity for folic acid and
for several reduced folic acid derivatives, and mediate delivery of
5-methyltetrahydrofolate to the interior of cells. This gene
includes two polymorphic variants; the shorter one has two base
deletion in the CDS, resulting in a truncated polypeptide, compared
to the longer one. Both protein products are constitutively
secreted in hematopoietic tissues and are potential serum marker
for certain hematopoietic malignancies. The longer protein has a
71% and 79% sequence homology with the FOLR1 and FOLR2 proteins,
respectively.1) O'Byrne, M.R., et al. Birth Defects Res. PartClin. Mol. Teratol. 88(8):689-694(2010)
Immunogen
This FOLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human FOLR3.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.