Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-51) Garg V., Kathiriya I. S., Barnes R., Schluterman M. K., King I. N., Butler C. A., Rothrock C. R., Eapen R. S., Hirayama-Yamada K., Joo K., Matsuoka R., Nature 424:443-447 (2003) Hirayama-Yamada K., Kamisago M., Akimoto K., Aotsuka H., Nakamura Y., Tomita H., Furutani M., Matsuoka R. Am. J. Med. Genet. A 135:47-52 (2005)
Immunogen
GATA-4 antibody was raised against a peptide sequence around aa.434~438 (D-S-H-G-D) derived from Human GATA-4.