Application
Western blot analysis of GDF6 in SK-N-SH lysate with GDF6 antibody at (A) 0.5 and (B) 1 μg/mL.| Product Name | GDF6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | GDF6 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. Both GDF6 and GDF7 are closely related to GDF5 which has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. In Xenopus, GDF6 is expressed at the edge of the neural plate and within the anterior neural plate including the eye fields. GDF6 is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. It may regulate patterning of the ectoderm by interacting with bone morphogenetic proteins (BMPs), and control eye development. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), a congenital disorder of spinal segmentation.1) Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol.6:597-641. |
| Immunogen | GDF6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human GDF6. The immunogen is located within amino acids 320 - 370 of GDF6. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| GDF6 antibody can be used for detection of GDF6 by Western blot at 0.5 to 1 μg/mL. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GDF6 |
|---|---|
| Alternative Names | GDF6 Antibody: KFM KFS KFS1 KFSL SGM1 BMP13 CDMP2 LCA17 MCOP4 SCDO4 MCOPCB6 GDF16GDF-6 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (100%) |
| Entrez Gene | 392255 |
|---|---|
| Protein Accession | NP_001001557 |
Application
Western blot analysis of GDF6 in SK-N-SH lysate with GDF6 antibody at (A) 0.5 and (B) 1 μg/mL.| Application Notes | GDF6 antibody can be used for detection of GDF6 by Western blot at 0.5 to 1 μg/mL. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | GDF6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | GDF6 Antibody is supplied in PBS containing 0.02% sodium azide. |
