The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene.1) Dong, L.Y., et al. Biochem. J. 431(2):277-287(2010) Li, W., et al. FEBS Lett. 584(18):3929-3935(2010) Daithankar, V.N., et al. Biochemistry 49(31):6737-6745(2010) Dayoub, R., et al. Biochem. Biophys. Res. Commun. 395(4):465-470(2010) Chang, J., et al. World J. Gastroenterol. 16(2):193-200(2010)
Immunogen
This GFER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human GFER.
Western blot analysis in MCF-7,U251 cell line and rat testis tissue lysates (35ug/lane).
Application
Western blot analysis in HepG2 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.