This gene encodes the gamma sunbunit of the
N-acetylglucosamine-1-phosphotransferase complex. This hexameric
complex, composed of alpha, beta and gamma subunits, catalyzes the
first step in synthesis of a mannose 6-phosphate lysosomal
recognition marker. This enzyme complex is necessary for targeting
of lysosomal hydrolases to the lysosome. Mutations in the gene
encoding the gamma subunit have been associated with mucolipidosis
IIIC, also known as mucolipidosis III gamma.1) Kang, C., et al. N. Engl. J. Med. 362(8):677-685(2010)
Immunogen
This GNPTG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-296 amino acids from the C-terminal region of human GNPTG.
Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.