This gene is a member of the G-protein coupled receptor 1
family and encodes a multi-pass membrane protein that localizes to
the endoplasmic reticulum. The protein binds estrogen, resulting in
intracellular calcium mobilization and synthesis of
phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This
protein therefore plays a role in the rapid nongenomic signaling
events widely observed following stimulation of cells and tissues
with estrogen. Alternate transcriptional splice variants which
encode the same protein have been characterized. [provided by
RefSeq].1) Patel, V.H., et al. Int. J. Mol. Med. 26(2):193-199(2010)
Immunogen
This GPER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from the C-terminal region of human GPER.
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Application
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.