Many proteins are tethered to the extracellular face of
eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI)
anchor. The GPI-anchor is a glycolipid found on many blood cells.
The protein encoded by this gene is a GPI degrading enzyme.
Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes
the inositol phosphate linkage in proteins anchored by
phosphatidylinositol glycans, thereby releasing the attached
protein from the plasma membrane.1) Speliotes, E.K., et al. Hepatology 52(3):904-912(2010)
Immunogen
This GPLD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-306 amino acids from the Central region of human GPLD1.
Phosphatidylinositol-glycan-specific phospholipase D PI-G PLD Glycoprotein phospholipase D Glycosyl-phosphatidylinositol-specific phospholipase D GPI-PLD GPI-specific phospholipase D GPLD1 PIGPLD1
Western blot analysis in HL-60 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.