Application
Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.| Product Name | GRINA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit |
| Product description | GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein). They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.1) Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18. |
| Immunogen | Rabbit polyclonal GRINA antibody was raised against an 18 amino acid peptide near the center of human GRINA. The immunogen is located within amino acids 110 - 160 of GRINA. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GRINA |
|---|---|
| Alternative Names | GRINA Antibody: LFG1 HNRGW TMBIM3 NMDARA1 LFG1 Protein lifeguard 1 NMDA receptor glutamate-binding subunit |
| Molecular Weight(MW) | Predicted: 41 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse: (94%) |
| Tissue Specificity | GRINA antibody is predicted to not cross-react with other members of the TMBIM family. |
| Entrez Gene | 2907 |
|---|---|
| Protein Accession | NP_001009184 |
Application
Western blot analysis of GRINA in human testis tissue lysate with GRINA antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1313 - Human Testis Tissue Lysate |
|---|---|
| Application Notes | GRINA antibody can be used for detection of GRINA by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | GRINA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | GRINA Antibody is supplied in PBS containing 0.02% sodium azide. |
