Application
Western blot analysis of extracts from NIH-3T3 tissue using HDAC6 (Phospho-Ser22) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | HDAC6 (phospho Ser22) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.1) Chen S, Owens GC, Makarenkova H, Edelman DB (2010)PLoS One 5, e10848. |
| Immunogen | HDAC6 (phospho Ser22) antibody was raised against a peptide sequence around phosphorylation site of serine 22 (P-Q-S (p)-P-P) derived from Human HDAC6. |
| Modification | p-Ser22 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | HDAC6 |
|---|---|
| Alternative Names | HD6 HDA6 Histone deacetylase 6 JM21 |
| Molecular Weight(MW) | 131 kDa |
| Tissue Specificity | The antibody detects endogenous level of HDAC6 only when phosphorylated at serine 22. |
| Entrez Gene | 10013 |
|---|---|
| Protein Accession | NP_006035.2 |
Application
Western blot analysis of extracts from NIH-3T3 tissue using HDAC6 (Phospho-Ser22) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
