Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.1) Petroziello J.,et al.Oncogene 23:7734-7745(2004).
Immunogen
This HEXIM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-269 amino acids from of human HEXIM2.
Western Blot at 1:8000 dilution Lane 1: mouse testis lysate Lane 2: U-2OS whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:8000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.