The HIRA protein shares sequence similarity with Hir1p
and Hir2p, the two corepressors of histone gene transcription
characterized in the yeast, Saccharomyces cerevisiae. The
structural features of the HIRA protein suggest that it may
function as part of a multiprotein complex. Recently, several
cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been
identified. In vitro, the HIRIP3 gene product binds HIRA, as well
as H2B and H3 core histones, indicating that a complex containing
HIRA-HIRIP3 could function in some aspects of chromatin and histone
metabolism.1) Kumar, R.A., et al. PLoS ONE(2), E4582 (2009) :
Immunogen
This HIRIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the Central region of human HIRIP3.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.