| Product Name |
HMGCR Monoclonal Antibody |
| Antibody Type |
Primary Antibodies |
| Antigen Alias |
HMGCR Monoclonal Antibody: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, HMG coenzyme A reductase, HMG CoAR, LDLCQ3 |
| Product description |
HMGCR Monoclonal Antibody: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by HMGCR. Normally in mammalian cells HMGCR is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of HMGCR induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.1) Goedeke L and Fernandez-Hernando C. Regulation of cholesterol homeostasis. Cell Mol. Life Sci. 2012; 69:915-30. |
| Immunogen |
Mouse monoclonal HMGCR antibody was raised against a 17 amino acid peptide near the amino terminus of human HMGCR. |
