This gene encodes a member of the hook family of
coiled-coil proteins, which bind to microtubules and organelles
through their N- and C-terminal domains, respectively. The encoded
protein localizes to discrete punctuate subcellular structures, and
interacts with several members of the Rab GTPase family involved in
endocytosis. It is thought to link endocytic membrane trafficking
to the microtubule cytoskeleton. Several alternatively spliced
transcript variants have been identified, but the full-length
nature of some of these variants has not been determined. [provided
by RefSeq].1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Immunogen
This HOOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-431 amino acids from the Central region of human HOOK1.
Western blot analysis in WiDr cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.