Homeobox protein Hox-B8, Homeobox protein Hox-24, Homeobox protein Hox-2D, HOXB8, HOX2D
Product description
This gene is a member of the Antp homeobox family and
encodes a nuclear protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17.
The encoded protein functions as a sequence-specific transcription
factor that is involved in development. Increased expression of
this gene is associated with colorectal cancer. Mice that have had
the murine ortholog of this gene knocked out exhibit an excessive
pathologic grooming behavior. This behavior is similar to the
behavior of humans suffering from the obsessive-compulsive spectrum
disorder trichotillomania.1) Kosaki, K., et al. Teratology 65(2):50-62(2002)
Immunogen
This HOXB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human HOXB8.
Western blot analysis in HL-60 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.