Homeobox protein Hox-D4, Homeobox protein HHOC13, Homeobox protein Hox-4B, Homeobox protein Hox-51, HOXD4, HOX4B
Product description
This gene belongs to the homeobox family of genes. The
homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all
multicellular organisms. Mammals possess four similar homeobox gene
clusters, HOXA, HOXB, HOXC and HOXD, located on different
chromosomes, consisting of 9 to 11 genes arranged in tandem. This
gene is one of several homeobox HOXD genes located at 2q31-2q37
chromosome regions. Deletions that removed the entire HOXD gene
cluster or 5' end of this cluster have been associated with severe
limb and genital abnormalities. The protein encoded by this gene
may play a role in determining positional values in developing limb
buds. Alternatively spliced variants have been described but their
full length nature has not been determined.1) Zhang, H., et al. Acta Pharmacol. Sin. 31(8):977-983(2010)
Immunogen
This HOXD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the C-terminal region of human HOXD4.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.