Histamine H2 receptor, H2R, HH2R, Gastric receptor I, HRH2
Product description
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Davila, S., et al. Genes Immun. 11(3):232-238(2010) Szukiewicz, D., et al. Inflamm. Res. 59 SUPPL 2, S205-S207 (2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Immunogen
This HRH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the Central region of human HRH2.
Western blot analysis in Uterus tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.