Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-β (Phospho-Ser23).| Product Name | IkB beta (phospho Ser23) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IKBB, TRIP9, HNF4, NR2A1, TCF14, I-kappa-B-beta, IKB-B, IKBB, NF-kappa-BIB, NF-kappaB inhibitor beta |
| Product description | Inhibits NF-κ-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-κ-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.1) Shirane, M. et al. (1999) J Biol Chem 274, 28169-28174. DiDonato J, et al. (1996) Mol Cell Biol 16 (4): 1295-304 |
| Immunogen | IkB-beta (Phospho-Ser23) antibody was raised against a peptide sequence around phosphorylation site of serine 23 (L-G-S (p) -L-G) derived from Human IkappaB-β. |
| Modification | p-Ser23 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| , Immunohistochemistry: 1:50~1:100: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NFKBIB |
|---|---|
| Alternative Names | IKBB TRIP9 HNF4 NR2A1 TCF14 I-kappa-B-beta IKB-B IKBB NF-kappa-BIB NF-kappaB inhibitor beta |
| Molecular Weight(MW) | 48 kDa |
| Tissue Specificity | This antibody detects endogenous level of IkappaB-β only when phosphorylated at serine 23. |
| Entrez Gene | 4793 |
|---|---|
| Protein Accession | NP_001001716.1 |
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-β (Phospho-Ser23).| Application Notes | , Immunohistochemistry: 1:50~1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
