Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IKK-γ (Phospho-Ser376) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | IKK-γ (phospho Ser376) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB |
| Product description | Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.1) Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999). |
| Immunogen | IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p)-S-P) derived from Human IKK-γ. |
| Modification | p-Ser376 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IKBKG |
|---|---|
| Alternative Names | FIP3 IKBKG IKKAP1 IKKG NF-kappaB |
| Molecular Weight(MW) | 48 kDa |
| Tissue Specificity | The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376. |
| Entrez Gene | 8517 |
|---|---|
| Protein Accession | NP_001093327.1 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using IKK-γ (Phospho-Ser376) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
