| Product Name | IL-23 p40 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Interleukin-23 Subunit p40; IL-23 Subunit p40; Interleukin-12 Subunit beta IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit; CLMF p40; IL-12 Subunit p40; NK Cell Stimulatory Factor Chain 2; NKSF2 |
| Product description | IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11). |
| Immunogen | Recombinant human IL-23p40. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1, k |
| Host Species | Mouse |
| Tested Applications | ELISAWB |
| ELISA: (direct or indirect: 1:500-1:10,000). Western blot: (1:500-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | IL12B |
|---|---|
| Alternative Names | Interleukin-23 Subunit p40 IL-23 Subunit p40 Interleukin-12 Subunit beta IL-12B Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit CLMF p40 IL-12 Subunit p40 NK Cell Stimulatory Factor Chain 2 NKSF2 |
| Tissue Specificity | Recognizes human IL-23p40. Does not cross-react with human IL-23p19. |
| Entrez Gene | 3593 |
|---|---|
| Protein Accession | NP_002178.2 |
| Application Notes | ELISA: (direct or indirect: 1:500-1:10,000). Western blot: (1:500-1:5,000 using ECL. Suggested blocking and dilution buffer is TBST with 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at rooom temperature). Optimal conditions should be determined individually for each application.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Stable for at least 1 year after receipt when stored at -20˚C. |
| Storage Buffer | Liquid. 0.2um-filtered solution in PBS, pH 7.4. Contains no preservatives. |
