Application
Immunohistochemistry of IL-36G in human bladder tissue with IL-36G antibody at 5 μg/mL.Application
Immunofluorescence of IL-36G in human bladder tissue with IL-36G antibody at 20 μg/mL.Application
Western blot analysis of IL-36G in human spleen tissue lysate with IL-36G antibody at (A) 1 and (B) 2 μg/ml.| Product Name | IL-36G Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL-36G Antibody: IL1E, IL1F9, IL1H1, IL-1F9, IL-1H1, IL1RP2, IL-1RP2, IL1E, UNQ2456/PRO5737, Interleukin-36 gamma, IL-1-related protein 2 |
| Product description | IL-36G is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36G is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2). Like the related proteins IL-36A and IL-36B, IL-36G requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3). IL-36G expression is stimulated by interferon-gamma, tumor necrosis factor-alpha and interleukin 1 (4). The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (5).1) Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75. |
| Immunogen | IL-36G antibody was raised against a 13 amino acid peptide near the carboxy terminus of human IL-36G. The immunogen is located within the last 50 amino acids of IL-36G. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| IL-36G antibody can be used for detection of IL-36G by Western blot at 1 - 2 μg/ml.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IL36G |
|---|---|
| Alternative Names | IL-36G Antibody: IL1E IL1F9 IL1H1 IL-1F9 IL-1H1 IL1RP2 IL-1RP2 IL1E UNQ2456/PRO5737 Interleukin-36 gamma IL-1-related protein 2 |
| Molecular Weight(MW) | Predicted: 19 kDa Observed: 22 kDa |
| Tissue Specificity | IL-36G antibody is human specific. IL-36G antibody will not cross-react with IL-36A or IL-36B. |
Application
Immunohistochemistry of IL-36G in human bladder tissue with IL-36G antibody at 5 μg/mL.
Application
Immunofluorescence of IL-36G in human bladder tissue with IL-36G antibody at 20 μg/mL.
Application
Western blot analysis of IL-36G in human spleen tissue lysate with IL-36G antibody at (A) 1 and (B) 2 μg/ml.| Positive Control | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
|---|---|
| Application Notes | IL-36G antibody can be used for detection of IL-36G by Western blot at 1 - 2 μg/ml.: |
| Form | Liquid |
|---|---|
| Storage Instructions | IL-36G antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | IL-36G antibody is supplied in PBS containing 0.02% sodium azide. |
