Application
Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 μg/mL.Application
Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 μg/mL.Application
Western blot analysis of IL-36RN in human spleen tissue lysate with IL-36RN antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.| Product Name | IL-36RN Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | IL-36RN Antibody: FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1(DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3 |
| Product description | IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).1) Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75. |
| Immunogen | IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN. The immunogen is located within the last 50 amino acids of IL-36RN. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μg/ml.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IL36RN |
|---|---|
| Alternative Names | IL-36RN Antibody: FIL1 FIL1D IL1F5 IL1L1 PSORP IL1HY1 IL1RP3 IL36RA FIL1(DELTA) UNQ1896/PRO4342 Interleukin-36 receptor antagonist protein FIL1 delta IL-1RP3 |
| Molecular Weight(MW) | Observed Molecular Weight: 24 kDa |
| Tissue Specificity | IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist |
Application
Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 μg/mL.
Application
Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 μg/mL.
Application
Western blot analysis of IL-36RN in human spleen tissue lysate with IL-36RN antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
|---|---|
| Application Notes | IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μg/ml.: |
| Form | Liquid |
|---|---|
| Storage Instructions | IL-36RN antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | IL-36RN antibody is supplied in PBS containing 0.02% sodium azide. |
