Application
Western blot analysis of lysed extracts from HL60 and HT29 cells using Integrin β3 (Ab-785).| Product Name | Integrin beta3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16, CD61 antigen, ITB3, Platelet membrane glycoprotein IIIa |
| Product description | The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with Alpha and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct Alpha subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-Alpha2B or the Itg-Beta3 subunit1) Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397 (Pt 3): 437–447Courter DL, et al. (2005) J Biol Chem Apr 01; 280 (13): 12145-12151Chandhoke SK, et al. (2004) J Cell Sci Mar 15; 117 (Pt 8): 1431-1441 |
| Immunogen | Integrin beta3 (Ab-785) antibody was raised against a peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ITGB3 |
|---|---|
| Alternative Names | GT CD61 GP3A BDPLT2 GPIIIa BDPLT16 CD61 antigen ITB3 Platelet membrane glycoprotein IIIa |
| Molecular Weight(MW) | 110 kDa |
| Tissue Specificity | This antibody detects endogenous level of total Integrin β3 protein. |
| Entrez Gene | 3690 |
|---|---|
| Protein Accession | NP_000203.2 |
Application
Western blot analysis of lysed extracts from HL60 and HT29 cells using Integrin β3 (Ab-785).| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
