Iron-sulfur (Fe-S) clusters are necessary for several
mitochondrial enzymes and other subcellular compartment proteins.
They contain sulfur and iron, and are created via several steps
that include cysteine desulfurases, iron donors, chaperones, and
scaffold proteins. This gene encodes the two isomeric forms, ISCU1
and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this
gene have been found in patients with myopathy with severe exercise
intolerance and myoglobinuria.1) Chen, Z., et al. Oncogene 29(30):4362-4368(2010)
Immunogen
This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.
Western blot analysis in mouse lung tissue lysates (35ug/lane).
Application
Western blot analysis in WiDr cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.